Publications
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Pagani L*#, León-Sampedro R*#, Amicone M, Tepekule-Muller B, Witzany C, Brugger S, de Vos M, Bakkeren E, Bottery
MJ, Mitri S, Opatowski L, Böttcher L, Faust K, Leventhal GE, Lehtinen S, Kouyos RD, Bonhoeffer S.
Nature Microbiology — DOI: https://doi.org/10.1038/s41564-026-02390-8
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Leon-Sampedro R#, Boumasmoud M, Reichlin M, Pfrunder-Cardozo KR, Noll N, Egli A, Hall AR.
Nature Communications 16(1):9733 — DOI: https://doi.org/10.1038/s41467-025-64714-2
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Pervasive transmission of a carbapenem resistance plasmid in the gut microbiota of hospitalized patients (2021)
León-Sampedro R, DelaFuente J, Díaz-Agero C, Crellen T, Musicha P, Rodríguez-Beltrán J, de la Vega C, Hernández-García M; R-GNOSIS WP5 Study Group; López-Fresneña N, Ruiz-Garbajosa P, Cantón R, Cooper BS, San Millán Á.
Nature Microbiology 6(5):606–616 — DOI: https://doi.org/10.1038/s41564-021-00879-y
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Clinical antibiotic-resistance plasmids have small effects on biofilm formation and population growth in Escherichia coli in vitro (2023)
Brülisauer L, León-Sampedro R, Hall AR.
Plasmid 128:102706 — DOI: https://doi.org/10.1016/j.plasmid.2023.102706
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Boumasmoud M, León-Sampedro R, Beusch V, Benz F, Arnoldini M, Hall AR.
Proc. Natl. Acad. Sci. U.S.A. 123(17):e2527793123 — DOI: https://doi.org/10.1073/pnas.2527793123
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Antibiotic-degrading resistance changes bacterial community structure via species-specific responses (2023)
Pathak A, Angst DC, León-Sampedro R, Hall AR.
The ISME Journal 17(9):1495–1503 — DOI: https://doi.org/10.1038/s41396-023-01465-2
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Within-patient evolution of plasmid-mediated antimicrobial resistance (2022)
DelaFuente J, Toribio-Celestino L, Santos-Lopez A, León-Sampedro R, Alonso-Del Valle A, Costas C, Hernández-García M, Cui L, Rodríguez-Beltrán J, Bikard D, Cantón R, San Millan A.
Nature Ecology & Evolution 6(12):1980–1991 — DOI: https://doi.org/10.1038/s41559-022-01908-7
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Variability of plasmid fitness effects contributes to plasmid persistence in bacterial communities (2021)
Alonso-Del Valle A, León-Sampedro R, Rodríguez-Beltrán J, DelaFuente J, Hernández-García M, Ruiz-Garbajosa P, Cantón R, Peña-Miller R, San Millán A.
Nature Communications 12(1):2653 — DOI: https://doi.org/10.1038/s41467-021-22849-y
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Beyond horizontal gene transfer: the role of plasmids in bacterial evolution (2021)
Rodríguez-Beltrán J, DelaFuente J, León-Sampedro R, MacLean RC, San Millán Á.
Nature Reviews Microbiology 19(6):347–359 — DOI: https://doi.org/10.1038/s41579-020-00497-1
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Phylogenomics of Enterococcus faecalis from wild birds: new insights into host-associated differences in core and accessory genomes of the species (2019)
León-Sampedro R, Del Campo R, Rodriguez-Baños M, Lanza VF, Pozuelo MJ, Francés-Cuesta C, Tedim AP, Freitas AR, Novais C, Peixe L, Willems RJL, Corander J, González Candelas F, Baquero F, Coque TM.
Environmental Microbiology 21(8):3046–3062 — DOI: https://doi.org/10.1111/1462-2920.14702
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Translational demand is not a major source of plasmid-associated fitness costs (2022)
Rodríguez-Beltrán J, León-Sampedro R, Ramiro-Martínez P, de la Vega C, Baquero F, Levin BR, San Millán Á.
Philosophical Transactions of the Royal Society B 377(1842):20200463 — DOI: https://doi.org/10.1098/rstb.2020.0463
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Collateral sensitivity associated with antibiotic resistance plasmids (2021)
Herencias C, Rodríguez-Beltrán J, León-Sampedro R, Alonso-Del Valle A, Palkovičová J, Cantón R, San Millán Á.
eLife 10:e65130 — DOI: https://doi.org/10.7554/eLife.65130
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Transfer dynamics of Tn6648, a composite integrative conjugative element generated by tandem accretion of Tn5801 and Tn6647 in Enterococcus faecalis (2019)
León-Sampedro R, Fernández-de-Bobadilla MD, San Millán Á, Baquero F, Coque TM.
Journal of Antimicrobial Chemotherapy 74(9):2517–2523 — DOI: https://doi.org/10.1093/jac/dkz239
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Diversity and Evolution of the Tn5801-tet(M)-Like Integrative and Conjugative Elements among Enterococcus, Streptococcus, and Staphylococcus (2016)
León-Sampedro R, Novais C, Peixe L, Baquero F, Coque TM.
Antimicrobial Agents and Chemotherapy 60(3):1736–1746 — DOI: https://doi.org/10.1128/AAC.01864-15
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Methods to Quantify DNA Transfer in Enterococcus (2020)
Novais C, Freitas AR, León-Sampedro R, Peixe L, Coque TM.
Methods in Molecular Biology 2075:111–122 — DOI: https://doi.org/10.1007/978-1-4939-9877-7_8
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Outbreak of NDM-1+CTX-M-15+DHA-1-producing Klebsiella pneumoniae high-risk clone in Spain owing to an undetectable colonised patient from Pakistan (2019)
Hernández-García M, Pérez-Viso B, León-Sampedro R, Navarro-San Francisco C, López-Fresneña N, Díaz-Agero C, Morosini MI, Ruiz-Garbajosa P, Cantón R.
International Journal of Antimicrobial Agents 54(2):233–239 — DOI: https://doi.org/10.1016/j.ijantimicag.2019.05.021
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Carbapenemases on the move: it's good to be on ICEs (2018)
Botelho J, Roberts AP, León-Sampedro R, Grosso F, Peixe L.
Mobile DNA 9:37 — DOI: https://doi.org/10.1186/s13100-018-0141-4
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First Report of an OXA-48- and CTX-M-213-Producing Kluyvera Species Clone Recovered from Patients Admitted in a University Hospital in Madrid, Spain (2018)
Hernández-García M, León-Sampedro R, Pérez-Viso B, Morosini MI, López-Fresneña N, Díaz-Agero C, Coque TM, Ruiz-Garbajosa P, Cantón R.
Antimicrobial Agents and Chemotherapy 62(11):e01238–18 — DOI: https://doi.org/10.1128/AAC.01238-18
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Antimicrobial Resistance in Enterococcus spp. of animal origin (2018)
Torres C, Alonso CA, Ruiz-Ripa L, León-Sampedro R, Del Campo R, Coque TM.
Microbiology Spectrum 6(4):ARBA-0032–2018 — DOI: https://doi.org/10.1128/microbiolspec.ARBA-0032-2018
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Detection of optrA in the African continent (Tunisia) within a mosaic Enterococcus faecalis plasmid from urban wastewaters (2017)
Freitas AR, Elghaieb H, León-Sampedro R, Abbassi MS, Novais C, Coque TM, Hassen A, Peixe L.
Journal of Antimicrobial Chemotherapy 72(12):3245–3251 — DOI: https://doi.org/10.1093/jac/dkx321
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Dissemination of Novel Antimicrobial Resistance Mechanisms through the Insertion Sequence Mediated Spread of Metabolic Genes (2016)
Furi L, Haigh R, Al Jabri ZJ, Morrissey I, Ou HY, León-Sampedro R, Martinez JL, Coque TM, Oggioni MR.
Frontiers in Microbiology 7:1008 — DOI: https://doi.org/10.3389/fmicb.2016.01008
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Multiple adaptive routes of Salmonella enterica Typhimurium to biocide and antibiotic exposure (2016)
Curiao T, Marchi E, Grandgirard D, León-Sampedro R, Viti C, Leib SL, Baquero F, Oggioni MR, Martinez JL, Coque TM.
BMC Genomics 17:491 — DOI: https://doi.org/10.1186/s12864-016-2778-z
