Multi-layered ecological interactions determine growth of clinical antibiotic-resistant strains within human microbiomes (2025)

León-Sampedro R, Boumasmoud M, Reichlin M, Pfrunder-Cardozo KR, Noll N, Egli A, Hall AR

Nat Commun 16(1):9733 — DOI: https://doi.org/10.1038/s41467-025-64714-2

Clinical antibiotic-resistance plasmids have small effects on biofilm formation and population growth in Escherichia coli in vitro (2023)

Brülisauer L, León-Sampedro R, Hall AR

Plasmid 128:102706 — DOI: https://doi.org/10.1016/j.plasmid.2023.102706

Antibiotic-degrading resistance changes bacterial community structure via species-specific responses (2023)

Pathak A, Angst DC, León-Sampedro R, Hall AR

ISME J 17(9):1495–1503 — DOI: https://doi.org/10.1038/s41396-023-01465-2

Within-patient evolution of plasmid-mediated antimicrobial resistance (2022)

DelaFuente J, Toribio-Celestino L, Santos-Lopez A, León-Sampedro R, Alonso-Del Valle A, Costas C, Hernández-García M, Cui L, Rodríguez-Beltrán J, Bikard D, Cantón R, San Millan A

Nat Ecol Evol 6(12):1980–1991 — DOI: https://doi.org/10.1038/s41559-022-01908-7

Translational demand is not a major source of plasmid-associated fitness costs (2022)

Rodríguez-Beltrán J, León-Sampedro R, Ramiro-Martínez P, de la Vega C, Baquero F, Levin BR, San Millán Á

Philos Trans R Soc Lond B Biol Sci 377(1842):20200463 — DOI: https://doi.org/10.1098/rstb.2020.0463

Variability of plasmid fitness effects contributes to plasmid persistence in bacterial communities (2021)

Alonso-Del Valle A, León-Sampedro R, Rodríguez-Beltrán J, DelaFuente J, Hernández-García M, Ruiz-Garbajosa P, Cantón R, Peña-Miller R, San Millán A

Nat Commun 12(1):2653 — DOI: https://doi.org/10.1038/s41467-021-22849-y

Pervasive transmission of a carbapenem resistance plasmid in the gut microbiota of hospitalized patients (2021)

León-Sampedro R, DelaFuente J, Díaz-Agero C, Crellen T, Musicha P, Rodríguez-Beltrán J, de la Vega C, Hernández-García M; R-GNOSIS WP5 Study Group; López-Fresneña N, Ruiz-Garbajosa P, Cantón R, Cooper BS, San Millán Á

Nat Microbiol 6(5):606–616 — DOI: https://doi.org/10.1038/s41564-021-00879-y

Collateral sensitivity associated with antibiotic resistance plasmids (2021)

Herencias C, Rodríguez-Beltrán J, León-Sampedro R, Alonso-Del Valle A, Palkovičová J, Cantón R, San Millán Á

Elife 10:e65130 — DOI: https://doi.org/10.7554/eLife.65130

Beyond horizontal gene transfer: the role of plasmids in bacterial evolution (2021)

Rodríguez-Beltrán J, DelaFuente J, León-Sampedro R, MacLean RC, San Millán Á

Nat Rev Microbiol 19(6):347–359 — DOI: https://doi.org/10.1038/s41579-020-00497-1

Methods to Quantify DNA Transfer in Enterococcus (2020)

Novais C, Freitas AR, León-Sampedro R, Peixe L, Coque TM

Methods Mol Biol 2075:111–122 — DOI: https://doi.org/10.1007/978-1-4939-9877-7_8

Transfer dynamics of Tn6648, a composite integrative conjugative element generated by tandem accretion of Tn5801 and Tn6647 in Enterococcus faecalis (2019)

León-Sampedro R, Fernández-de-Bobadilla MD, San Millán Á, Baquero F, Coque TM

J Antimicrob Chemother 74(9):2517–2523 — DOI: https://doi.org/10.1093/jac/dkz239

Outbreak of NDM-1+CTX-M-15+DHA-1-producing Klebsiella pneumoniae high-risk clone in Spain owing to an undetectable colonised patient from Pakistan (2019)

Hernández-García M, Pérez-Viso B, León-Sampedro R, Navarro-San Francisco C, López-Fresneña N, Díaz-Agero C, Morosini MI, Ruiz-Garbajosa P, Cantón R

Int J Antimicrob Agents 54(2):233–239 — DOI: https://doi.org/10.1016/j.ijantimicag.2019.05.021

Phylogenomics of Enterococcus faecalis from wild birds: new insights into host-associated differences in core and accessory genomes of the species (2019)

León-Sampedro R, Del Campo R, Rodriguez-Baños M, Lanza VF, Pozuelo MJ, Francés-Cuesta C, Tedim AP, Freitas AR, Novais C, Peixe L, Willems RJL, Corander J, González Candelas F, Baquero F, Coque TM

Environ Microbiol 21(8):3046–3062 — DOI: https://doi.org/10.1111/1462-2920.14702

Carbapenemases on the move: it's good to be on ICEs (2018)

Botelho J, Roberts AP, León-Sampedro R, Grosso F, Peixe L

Mob DNA 9:37 — DOI: https://doi.org/10.1186/s13100-018-0141-4

First Report of an OXA-48- and CTX-M-213-Producing Kluyvera Species Clone Recovered from Patients Admitted in a University Hospital in Madrid, Spain (2018)

Hernández-García M, León-Sampedro R, Pérez-Viso B, Morosini MI, López-Fresneña N, Díaz-Agero C, Coque TM, Ruiz-Garbajosa P, Cantón R

Antimicrob Agents Chemother 62(11):e01238–18 — DOI: https://doi.org/10.1128/AAC.01238-18

Antimicrobial Resistance in Enterococcus spp. of animal origin (2018)

Torres C, Alonso CA, Ruiz-Ripa L, León-Sampedro R, Del Campo R, Coque TM

Microbiol Spectr 6(4):ARBA-0032–2018 — DOI: https://doi.org/10.1128/microbiolspec.ARBA-0032-2018

Detection of optrA in the African continent (Tunisia) within a mosaic Enterococcus faecalis plasmid from urban wastewaters (2017)

Freitas AR, Elghaieb H, León-Sampedro R, Abbassi MS, Novais C, Coque TM, Hassen A, Peixe L

J Antimicrob Chemother 72(12):3245–3251 — DOI: https://doi.org/10.1093/jac/dkx321

Dissemination of Novel Antimicrobial Resistance Mechanisms through the Insertion Sequence Mediated Spread of Metabolic Genes (2016)

Furi L, Haigh R, Al Jabri ZJ, Morrissey I, Ou HY, León-Sampedro R, Martinez JL, Coque TM, Oggioni MR

Front Microbiol 7:1008 — DOI: https://doi.org/10.3389/fmicb.2016.01008

Multiple adaptive routes of Salmonella enterica Typhimurium to biocide and antibiotic exposure (2016)

Curiao T, Marchi E, Grandgirard D, León-Sampedro R, Viti C, Leib SL, Baquero F, Oggioni MR, Martinez JL, Coque TM

BMC Genomics 17:491 — DOI: https://doi.org/10.1186/s12864-016-2778-z

Diversity and Evolution of the Tn5801-tet(M)-Like Integrative and Conjugative Elements among Enterococcus, Streptococcus, and Staphylococcus (2016)

León-Sampedro R, Novais C, Peixe L, Baquero F, Coque TM

Antimicrob Agents Chemother 60(3):1736–1746 — DOI: https://doi.org/10.1128/AAC.01864-15